It is pretty hard to carve out a happy place when looking at Russell Wilson for today's game, but we can at least have hope in that Rex has a very good record against rookie or very inexperienced QBs (I believe their rating is in the 60s). I dug around Pro Football Focus (PFF) to see if I can could find other small pieces of good news.
1. Pressure - Wilson is the 3rd most frequently pressured QB in the league, 38% of dropbacks (only Kolb and Vick more so). Never mind that he is very good (11th in accuracy percentage) under pressure, and very hard to sack, and that we don't pressure the QB that well. At least if there is a QB we can just throw the house at and hope to confuse he has been pressured a bunch. At least if Rex dials up some blitzes we should see some action.
2. The Deep Pass - Wilson is 2nd in the league in deep pass (over 20 yards in the air) frequency, throwing deep 15% of dropbacks (he also, sadly, is 8th in the league in accuracy percentage when doing so). But...he is tied for the lead in INTs thrown when tossing deep with 4. We have an athletic ball hawk in Cromartie, could one be going the other way? Okay, we'll pretend that Wilson getting burned didn't just pop into my mind.
3. Don't Fear the Play Action - Only 1 QB uses play action more than Russell Wilson who uses it on 33.2% of his pass attempts (and that is RG3), but Wilson actually has experienced a pretty deep drop off in play action. His QB rating is 62.5 when using play action, and 90.1 when not. He is also tied for play action INTs with Micheal Vick, 4. There isn't a ton to hang your hat on here, but at least when you see those 1 out of 3 play action pass drop backs you can hope that something bad might happen.