The Denver Broncos have not been able to run the ball effectively this season. The numbers do not lie. They rank last in the league with 51.8 yards on the ground per game. They average 2.3 yards per carry. Football Outsiders rates their line as the worst run blocking unit in the game.
The only place FO says the Broncos run the ball even at the league average is to the right end. They rank 27th or worse going everywhere else. It might be a good idea to stick Sione Pouha at end to counter this and stick Mike Devito in the middle.
This is not unheard of. Rex Ryan did it with Haloti Ngata in Baltimore. The Patriots frequently do it with Vince Wilfork against Miami to create a more favorable matchup. Given the way Devito is playing, he should be able to win matchups against J.D. Walton and the rest of Denver's interior line. It would make sense to stick the strongest run defender to counter against the only place the Broncos can effectively run it.